|
KMID : 1009020160140030279
|
|
Clinical Psychopharmacology and Neuroscience
2016 Volume.14 No. 3 p.279 ~ p.285
|
|
|
Differential Effects of Olanzapine and Haloperidol on MK-801-induced Memory Impairment in Mice
|
|
Song Jae-Chun
Seo Mi-Kyoung
Park Sung-Woo
Lee Jung-Goo
Kim Young-Hoon
|
|
|
Abstract
|
|
|
Objective : We investigated the differential effects of the antipsychotic drugs olanzapine and haloperidol on MK-801-induced memory impairment and neurogenesis in mice.
Methods : MK-801 (0.1 mg/kg) was administered 20 minutes prior to behavioral testing over 9 days. Beginning on the sixth day of MK-801 treatment, either olanzapine (0.05 mg/kg) or haloperidol (0.05 mg/kg) was administered 40 minutes prior to MK-801 for the final 4 days. Spatial memory performance was measured using a Morris water maze (MWM) test for 9 days (four trials/day). Immunohistochemistry with bromodeoxyuridine (BrdU) was used to identify newborn cells labeled in tissue sections from the dentate gyrus of the hippocampus.
Results : MK-801 administration over 9 days significantly impaired memory performance in the MWM test compared to untreated controls (p<0.05) and these deficits were blocked by treatment with olanzapine (p<0.05) but not haloperidol. The administration of MK-801 also resulted in a decrease in the number of BrdU-labeled cells in the dentate gyrus (28.6%; p<0.01), which was prevented by treatment with olanzapine (p<0.05) but not haloperidol.
Conclusion : These results suggest that olanzapine has a protective effect against cognitive impairments induced by MK-801 in mice via the stimulating effects of neurogenesis.
|
|
|
KEYWORD
|
|
|
Olanzapine, Haloperidol, Memory, NMDA antagonist, Neurogenesis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|